Role of melanization in pathogenesis and progression of melanoma (Anna Brożyna, PhD).
Involvement of the endocrine system of vitamin D3 in the biology of skin melanocytic tumors (Anna Brożyna, PhD).
Molecular foundations of tumorigenesis, diagnostic and prognostic markers of human cancer (Anna Brożyna, PhD; Łukasz Kuźbicki, PhD), in particular:
molecular markers of cancerogenesis, especially markers useful for detection of cutaneous melanoma as well as prognostic and predictive markers for this cancer,
epigenetic modifications in development and progression of human melanoma.
Examination of active DNA demethylation processes (analysis of the expression level of genes and proteins associated with active DNA demethylation: TET1, TET2, TET3, TDG, AID/APOBEC, IDH1, IDH2, HIF1-α, HIF2-α, as well as analysis of product levels of this process: 5-methylcytosine and its derivatives) in breast cancer, colorectal cancer, prostate cancer, leukemias (Kinga Linowiecka, PhD).
